Brechin are hopeful goalkeeper Craig Nelson will recover from an injury sustained in the first leg while midfielder Mark Docherty should play.Defender Jon Seeley misses out through work commitments while Anton Kurakins, Willie Dyer, Alex Walker and Neil Janczyk are all out injured.
Cowdenbeath defender Kenny Adamson is suspended for the trip to Brechin.
Fellow centre back Dene Droudge and midfielder Danny MacKay both miss out through injury.
Brechin City manager Jim Duffy: "I will tell the players to be relaxed and go out and enjoy it. However, I know it will be a nervy encounter and the team with the players that handle it better will win."
Cowdenbeath manager Danny Lennon: "We have done well this season but in reality it counts for nothing if we do not win this game.
"A year ago we left Ochilview feeling very low and I told the players to remember how bad it felt. I have reminded them of that pain in the build up to this game."
Source: BBC Sport
Source: BBC Sport